Alchemab Therapeutics is a pioneering biotech company based in Cambridge, UK. We use a unique platform to identify novel drug targets and therapeutics by analysing antibody repertoires of patients who are resilient to disease. Our work spans neurodegeneration and oncology, built on a foundation of deep science, cutting-edge technology, and a passionate team committed to transforming lives.

Led by world-renowned scientist Dr. Jane Osbourn, our team is driven by four core values:

🧬 Think Patient First – Everything we do is rooted in positively impacting patients
🤝 Achieve As One – Collaboration and mutual support power our progress
💪 Embrace Responsibility – Every team member is empowered to make a difference
🌱 Create Something Enduring – We're building solutions for today and tomorrow

The Industrial Placement Programme

We’re looking for a highly motivated student to join us for a 9–12 month industrial placement. This is a unique opportunity to contribute to core platform development at the heart of Alchemab’s discovery engine, while gaining hands-on experience across both Research and Translational teams.

You’ll work on a dedicated project, supported by experienced scientists, with the opportunity to make meaningful contributions to ongoing scientific programmes. Alongside your project work, you’ll receive mentoring and development support to help you grow your technical and professional skills.

🔍 Project Title - Development of Transcriptomic Platforms for BCRseq and Biomarker Discovery & Detection

🧪 Project Overview

This placement sits at the interface of research and translational biology, focusing on RNA-based technologies that underpin antibody discovery and downstream biomarker analysis.

The project is divided into two complementary phases

1. BCRseq Platform Optimisation (Research Team)

Alchemab’s bulk B cell receptor sequencing (BCRseq) platform is central to our discovery of antibodies. While robust, it has not been systematically optimised in recent years despite the introduction of new sample types and workflows.

You will evaluate and compare RNA extraction methods and cDNA generation strategies across multiple sample input types to identify opportunities for optimisation or increased robustness. This work will directly contribute to improving sequencing quality and ensuring adaptability to diverse sample inputs.

2. Transcriptomic Applications for Translational Science (Translational Team)
Building on this foundation, you will apply your learnings to gene expression analysis workflows. Specifically, you will explore how transcriptional changes downstream of target engagement can inform mechanism of action and biomarker strategies.

A key focus will be the development and comparison of qPCR-based approaches, including evaluation of different chemistries, reagents, and workflows. The aim is to establish a standardised, scalable approach for gene expression analysis across projects.

🎯 Project Goals

Gain hands-on experience with Alchemab’s bulk BCRseq workflow
• Evaluate RNA extraction methods across a range of sample types
• Assess and optimise cDNA generation approaches within sequencing workflows
• Apply transcriptomic techniques to translational assays (e.g. qPCR, RNAseq)
• Compare qPCR chemistries (e.g. SYBR Green vs TaqMan) and define best practices
• Propose improved and standardised protocols for future use

🧪 Techniques & Technologies You’ll Use

RNA extraction from diverse biological samples
• RNA quantification and quality assessment
• cDNA synthesis and library preparation
• Bulk BCR sequencing workflows
• Data analysis and visualisation (e.g. R)
• Cell and tissue culture, including primary cells
• Quantitative PCR (qPCR)

📘 What You’ll Learn

By the end of your placement, you will:

Develop a strong foundation in RNA biology and sequencing workflows
• Understand how BCR repertoire sequencing supports antibody discovery
• Gain experience optimising experimental workflows and evaluating methodologies
• Learn how gene expression analysis informs mechanism of action and biomarker discovery
• Experience both early discovery research and translational development stages
• Build practical lab, data analysis, and scientific communication skills

🌟 Why This Placement is Right for You

This project offers a rare opportunity to contribute to core platform development while also seeing how those technologies are applied in a translational context.

You’ll have the chance to take ownership of experimental design and decision-making—testing hypotheses such as optimal RNA extraction or cDNA generation methods—and directly influence how these workflows are implemented across the company.

By working across both Research and Translational teams, you’ll gain a broad perspective on the drug discovery pipeline, from early antibody discovery through to biomarker strategy and clinical relevance.

Your work will have tangible impact—helping to future-proof Alchemab’s BCRseq platform and establish robust transcriptomic workflows that support multiple programmes.

🧠 Requirements

Currently pursuing a BSc in a biological or life sciences-related discipline
• At least 1 year of undergraduate study completed at time of application
• Strong interest in molecular biology, transcriptomics, or biotechnology
• Excellent attention to detail and organisational skills
• Strong analytical thinking and problem-solving ability
• Good communication and teamwork skills
• Eligibility to work in the UK for the duration of the placement

🌿 Where You’ll Be Working

You’ll be based in Whittlesford, just south of Cambridge, in a state-of-the-art biotech facility with excellent transport links to Cambridge and London.

🎉 Connecting, Celebrating, and Giving Back

At Alchemab, we believe great science thrives in a strong, connected community. From social events to charity initiatives, there are plenty of opportunities to connect, have fun, and make a difference beyond the lab.

Please note

The successful candidate will be employed by SRG and based on-site at Alchemab Therapeutics. Candidate details will only be shared with SRG at offer stage, in line with data protection standards.

📅 Recruitment Process

Application deadline: 8th May 2026
• Application: Please apply via the link and include a cover letter outlining your interest in Alchemab and this placement opportunity
• Screening: Applications will be reviewed by supervisors following the deadline
• Interviews: Expected to take place between 18th –29th May (flexible window), ideally face-to-face where possible
• Offers: Decisions and offers are expected to be finalised in early June

Apply now

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