RA Capital

Why Join Us?

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and AR^ON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The Senior Manager, Supply Chain will lead the end-to-end operational management of investigational product (IP) and clinical trial materials across global Phase I–III studies. This role is responsible for ensuring timely, compliant, and efficient delivery of clinical supplies, while partnering cross-functionally with Clinical Operations, Quality, Regulatory, CMC, and external vendors to support study execution.

• Develop and maintain study-level supply plans and forecasts aligned with enrollment, protocol design, and site activation timelines
• Coordinate packaging, labeling, release, and global distribution of investigational products and ancillary materials
• Oversee inventory across depots and study sites, proactively mitigating risks to avoid shortages or excess
• Serve as business owner of the IRT system, including setup, configuration, validation, and ongoing management
• Partner cross-functionally to align supply strategy with clinical and regulatory requirements and ensure seamless execution
• Author and maintain supply-related documentation, including SOPs, Pharmacy Manuals, and study-specific materials
• Ensure compliance with GxP, GDP, and ICH-GCP standards, supporting audits and inspection readiness
• Manage global logistics, vendor oversight, and third-party partners to ensure uninterrupted supply across regions

What you’ll need to be successful:

• Bachelor’s degree in Supply Chain, Life Sciences, or related field (Master’s preferred)
• Minimum 5 years of global clinical supply chain experience within biotech, pharma, or medical device
• Hands-on experience with IRT/IXRS systems (e.g., 4G Clinical, Almac, Endpoint)
• Experience supporting global Phase I–III clinical trials (commercial launch experience preferred)
• Proficiency with Microsoft Office and inventory/ERP systems
• Strong understanding of GxP, GDP, and ICH-GCP regulations
• Proven ability to manage complex global supply operations and mitigate risk
• Strong analytical, organizational, and problem-solving skills
• Effective cross-functional collaboration and communication across internal teams and external partners
• Experience drafting SOPs, Pharmacy Manuals, and clinical supply documentation preferred
• Familiarity with cold chain and temperature-controlled distribution preferred
• APICS/CSCP or PMP certification a plus
• Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus
• Able to work on-site and attend in-person meetings
• Ability to travel up to 15%

Core Values

Parabilis is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent.We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused.We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In.We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary target for this position is $153,000-$180,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com