RA Capital

Summary: Typewriter Therapeutics, Inc. of Japan (Typewriter TX Japan GK) is seeking a highly motivated, collaborative and resourceful scientist with extensive experience in pharmacology for drug discovery. The successful candidate will lead/oversee the execution of internal program(s). She/he will be pushing the boundaries of our proprietary gene delivery technology within the realm of diseases. This role presents a unique opportunity to explore the multifaceted applications of gene writing for diseases, paving the way for novel therapeutic programs and potential partnerships that could redefine the landscape of genetic medicine. The successful candidate will oversee the execution of program-related activities, from target identification, target validation, drug candidate nomination and regulatory filings. The successful candidate will be a collaborative and energetic scientist with superior communication skills, who can establish and ultimately lead a cross-functional lab-based team running multiple projects, act as scientific leader and seek and establish novel methods and processes to enhance projects across several Disease Research areas. Reporting to the Sr. Princ Sci/Head of R&D Japan, Gene Therapy, this position has vast learning opportunities in the field of permanent gene insertion into the genome, while working in a fast-paced cross-functional team setting. Position Responsibilities- Contribute to the internal therapeutic strategy- Lead the execution of internal programs and develop the path to candidate, including Go/no-go decision, from target identification, validation (on and off target), in vitro and in vivo proof-of-principle for program-related gene delivery molecules- Manage the work of others directly as well as in a matrixed structure- Work collaboratively with stakeholders across global Typewriter Therapeutics including but not limited to the molecular, cell biology, nonclinical, bioanalytical, CMC and formulation teams- Critically analyze data generated to inform scientific program strategy, program decisions and subsequent stages of drug development- Oversee group communication of study results to the project teams and to internal and external stakeholders in English as well as Japanese- Support evaluation of Business Development (BD) opportunities and patent filing- Act as a scientific mentor and role model, supporting the Typewriter Therapeutics culture Qualifications- PhD in Molecular and Cell Biology or related degrees, with 8+ years of relevant experience or BS/MS with 15+ years of relevant experience in a similar life sciences-related field- Experience in drug discovery research with demonstrated proficiency in diseases- Expertise in one therapeutic modality required (gene editing or gene therapy) and familiarity with other modalities a plus- Expertise in designing and overseeing execution of in vitro/in vivo pharmacology studies in relevant cell types for the evaluation of drug candidates for the treatment of diseases; experience in IND filing is a plus- Expertise in designing and validating cell-based biochemical, enzymatic assays is required- Knowledge of animal models of disease, such as rare monogenic diseases- Experience with molecular analysis of in vitro and in vivo gene insertion outcomes using next-generation sequencing, long range sequencing, quantitative PCR, and RNA sequencing is a plus- Experience in managing direct reports and setting team priorities- Thrives in a fast-moving, results-oriented startup environment- Self-motivated, passionate, and eager to continuously learn- Flexible, cooperative, can-do attitude Working Conditions- Salary: ¥10,000,000 – ¥13,000,000 per year (subject to increase based on performance)- Bonus: None (0 times per year)- Commuting Expenses: Fully covered within company policy- Relocation Expenses: Partially covered (negotiable)- Work Location and Transfer Scope: Initial location: Kashiwa-no-ha Office; possible relocation within the Kanto area- Contract Term: No fixed term; mandatory retirement at age 60, with possible re-employment up to age 65- Probation Period: 3 months; Working Conditions During Probation: Same as regular employment- Scope of Job Duties: No changes in principle- Working Hours: Discretionary labor system; deemed working hours: 8 hours, standard 9:00–18:00- Break Time: 60 minutes- Annual Holidays: Weekends and national holidays; special paid leave during Obon and New Year holidays; 10 days of paid leave after 6 months; no hourly paid leave; substitute holidays available- Overtime Work: None (discretionary labor allowance equivalent to 20 hours/month included in salary)- Social Insurance: Health insurance, welfare pension, employment insurance, workers’ compensation insurance- Smoking Policy: Smoking is strictly prohibited in the workplace Contact: Typewriter TX Japan GK, 5-4-6-613, Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan; E-mail: recruitjp@typewritertx.com