Summary: Typewriter Therapeutics, Inc. of Japan (Typewriter TX Japan GK) is seeking a highly motivated, collaborative and resourceful scientist with extensive experience in pharmacology for drug discovery. The successful candidate will lead/oversee the execution of internal program(s), pushing the boundaries of our proprietary gene delivery technology within the realm of diseases. This role presents a unique opportunity to explore the multifaceted applications of gene writing for diseases, paving the way for novel therapeutic programs and potential partnerships that could redefine the landscape of genetic medicine. The candidate will oversee program-related activities from target identification and validation to drug candidate nomination and regulatory filings. Reporting to the Sr. Princ Sci/Head of R&D Japan, this position offers vast learning opportunities in permanent gene insertion while working in a fast-paced cross-functional team setting. Position Responsibilities- Contribute to the internal therapeutic strategy- Lead the execution of internal programs and develop the path to candidate, including Go/No-Go decisions, from target identification and validation (on/off target) to in vitro and in vivo proof-of-principle for program-related gene delivery molecules- Manage the work of others directly and in a matrixed structure- Collaborate with global stakeholders across molecular biology, cell biology, nonclinical, bioanalytical, CMC, and formulation teams- Critically analyze data to inform program strategy, decisions, and subsequent drug development stages- Oversee communication of study results to project teams and internal/external stakeholders in English and Japanese- Support evaluation of Business Development opportunities and patent filing- Act as a scientific mentor and role model, supporting company culture Qualifications- PhD in Molecular and Cell Biology or related field with 8+ years of relevant experience, or BS/MS with 15+ years of relevant experience- Experience in drug discovery research with demonstrated proficiency in diseases- Expertise in one therapeutic modality (gene editing or gene therapy) required; familiarity with others a plus- Expertise in designing and overseeing in vitro/in vivo pharmacology studies for evaluation of drug candidates; IND filing experience a plus- Expertise in designing and validating cell-based biochemical and enzymatic assays- Knowledge of animal models of disease, such as rare monogenic diseases- Experience with molecular analysis of gene insertion outcomes using NGS, long-range sequencing, qPCR, and RNA-seq is a plus- Experience managing direct reports and setting team priorities- Thrives in a fast-moving, results-oriented startup; self-motivated, passionate, eager to learn; flexible, cooperative, can-do attitude Working Conditions- Salary: ¥10,000,000 – ¥13,000,000 per year (subject to performance-based increases)- Bonus: None (0 times per year)- Commuting Expenses: Fully covered within company policy- Relocation Expenses: Partially covered (negotiable)- Work Location: Initial location Kashiwa-no-ha Office; possible relocation within the Kanto area due to future office moves- Contract Term: No fixed term; retirement at age 60, with possible re-employment up to age 65- Probation Period: 3 months (no change in conditions)- Working Hours: Discretionary labor system; deemed 8 hours/day, standard 9:00–18:00- Break Time: 60 minutes- Annual Holidays: Weekends and national holidays; special paid leave during Obon and New Year holidays; 10 days of paid leave after 6 months; substitute leave available- Overtime: None (fixed allowance equivalent to 20 hours/month included)- Social Insurance: Health insurance, pension, employment insurance, workers’ compensation- Smoking Policy: No smoking on the premises