RA Capital

Summary: Typewriter Therapeutics, Inc. of Japan (Typewriter TX Japan GK) is seeking a highly motivated, collaborative and resourceful scientist with extensive experience in pharmacology for drug discovery. The successful candidate will lead/oversee the execution of internal program(s). She/he will push the boundaries of our proprietary gene delivery technology within the realm of diseases. This role presents a unique opportunity to explore multifaceted applications of gene writing for diseases, paving the way for novel therapeutic programs and potential partnerships that could redefine genetic medicine. Reporting to the Sr. Princ Sci/Head of R&D Japan, this position offers vast learning opportunities in permanent gene insertion while working in a fast-paced cross-functional team setting. Position Responsibilities- Contribute to the internal therapeutic strategy- Lead the execution of internal programs and develop the path to candidate (including Go/No-Go decisions) from target identification, validation (on- and off-target), and in vitro/in vivo proof-of-principle for program-related gene delivery molecules- Manage the work of others directly and in a matrixed structure- Collaborate with global stakeholders across Typewriter Therapeutics, including molecular biology, cell biology, nonclinical, bioanalytical, CMC, and formulation teams- Critically analyze data to inform scientific program strategy, decisions, and subsequent stages of drug development- Oversee communication of study results to project teams and to internal/external stakeholders in English and Japanese- Support evaluation of Business Development (BD) opportunities and patent filing- Act as a scientific mentor and role model, supporting company culture Qualifications- PhD in Molecular/Cell Biology or related field with 8+ years relevant experience, or BS/MS with 15+ years relevant experience in a similar life sciences-related field- Drug discovery research experience with demonstrated proficiency in diseases- Expertise in one therapeutic modality (gene editing or gene therapy) required; familiarity with other modalities a plus- Expertise in designing and overseeing in vitro/in vivo pharmacology studies for evaluation of drug candidates; IND filing experience is a plus- Expertise in designing and validating cell-based biochemical, enzymatic assays- Knowledge of animal models of disease, such as rare monogenic diseases- Experience with molecular analysis of in vitro/in vivo gene insertion outcomes using NGS, long-range sequencing, qPCR, and RNA-seq is a plus- Experience managing direct reports and setting team priorities- Thrives in a fast-moving, results-oriented startup environment; self-motivated and eager to learn; flexible, cooperative, can-do attitude Working Conditions- Salary: ¥10,000,000 – ¥13,000,000 per year (subject to increase based on performance)- Bonus: None (0 times per year)- Commuting expenses: Fully covered within company policy- Relocation expenses: Partially covered (negotiable)- Work location and transfer scope: Initial location Kashiwa-no-ha Office; possible relocation within the Kanto area due to future office moves- Contract term: No fixed term; mandatory retirement at 60, with possible re-employment up to 65- Probation period: 3 months; same working conditions during probation- Working hours: Discretionary labor system; deemed 8 hours/day; standard 9:00–18:00; actual hours at employee’s discretion- Break time: 60 minutes- Annual holidays: Weekends and national holidays; special paid leave during Obon and New Year; 10 days paid leave after 6 months; no hourly paid leave; substitute holidays available- Overtime work: None (20 hours/month allowance included in salary)- Social insurance: Health, pension, employment, workers’ compensation- Smoking policy: No smoking on the premises