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Principal Scientist, DMPK

Ventus Therapeutics

Montreal, CA
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Drug Discovery and Tools
  • Post Date: 05/23/2023
  • Website:
  • Company Address: 100 Beaver St, Suite 202, Waltham, MA, 02453

About Ventus Therapeutics

Platform for structure-based drug discovery to target difficult-to-drug proteins

Job Description

About us:

Ventus Therapeutics is a biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets, with an initial focus on immunology, inflammation and neurology.


Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop medicines through unique insights into protein targets and to create dynamic blueprints that can guide the development of differentiated small molecule medicines. Our lead programs target key innate immune modulators, including NLRP3 and cGAS. We aim to use the ReSOLVE platform to improve the way medicines are discovered and developed, with the ultimate goal of restoring the health of people facing serious illnesses.


Position Overview:

Ventus is seeking an experienced DMPK scientist. We are looking for a talented, collaborative and dynamic scientist to support our research efforts, responsible for planning and performing PK/ADME studies, and contributing to DMPK strategy to support Ventus research and development activities. The candidate will be responsible for communicating experimental results to the project team, and works cross-functionally with internal teams and external resources as appropriate.



· Under limited direction, plans and executes in vivo PK/ADME studies, and interprets and communicates results as part of a multi-disciplinary team.

· Collaborates with chemists to help drive SAR, by proposing in vitro and in vivo strategies aiming at optimizing ADME properties.

· Serves as DMPK representative on project teams, interprets and presents data/results to cross-functional teams.

· Interprets in vitro DDI data and assess DDI risk potential.

· Contribute to elaboration of relevant DMPK documents for development candidate nomination and IND/NDA filings.



· M.Sc. in Chemistry, Biology, Pharmaceutical science, Pharmacology or related scientific discipline.

· 5+ years of industry experience in PK/ADME in drug research & development.

· Experience in small molecules is required.

· Hands-on experience analyzing PK data and building PK/PD relationships using relevant software programs such as WinNonlin.

· Hands-on experience performing ADME in vitro assays such as metabolic stability, protein binding, CYP inhibition, permeability.

· Strong working knowledge of concepts related to ADME of drugs, routes of drug administration, pharmacokinetic modeling, and bioanalysis.

· Sound understanding of regulatory guidance related to ADME/PK characterization and drug-drug interactions.

· Excellent communication skills with an ability to communicate across a variety of audiences including team members and cross-functional project teams.

· Ability to work independently and collaboratively in a fast-paced environment.

· Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.