- Job Type: Full-Time
- Function: Research Sci/Assoc/Mgr
- Industry: Oncology
- Post Date: 03/15/2023
- Website: www.vorbio.com
- Company Address: 100 Cambridgepark Dr, Suite 101, Cambridge, MA, 02140
- Salary Range: NA
About Vor Bio
Hematopoietic stem cells to optimize stem cell transplants for cancerJob Description
We make healthy cells invisible to targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively invisible to targeted therapies. Diseased cells displaying the target protein and are then vulnerable to attack. This process potentially broadens the therapeutic window and improves the utility of complementary targeted therapies.
What we value in our fellow Voracians
Passion: Enthusiastically driving our science toward innovative medicines
Fellowship: Fostering genuine bonds of collaboration and mentorship
Humility: Acting selflessly by putting the collective mission first
Who we are looking for:
Vor Bio is seeking a Scientist/Senior Scienist who will help advance the evaluation and implementation of the editing tools needed for engineering Vor’s hematopoietic stem cell products. This will involve working within a team environment to enable multiplexed gene editing and rare disease in the Discovery and Molecular Engineering team.
Key areas of responsibilities:
- Technical leadership of Vor’s gene editing technologies platform, focusing on nucleases and base editors
- Work with genome engineering, discovery platform and quantitative biology technical leads to implement new technologies through target design/screening and assay development
- Oversee Vor’s mRNA platform to support evaluation and usage of gene editing tools
- Design, make and evaluate various editing tools in mRNA or protein formats to support multiplexed editing in primary cells
- Collaborate with other teams to improve ex-vivo delivery methods
- Oversee CRO activities and external collaborations on sourcing gene editing tools as needed
- Attend and present at cross-functional team meetings frequently
- Supervise and mentor associate scientists
Qualifications:
- PhD in a relevant scientific discipline with 2-4 years of relevant experience
- Strong molecular biology background, including deep understanding of RNA and protein biochemistry
- Prior experience in gene editing or genomics using CRISPR-Cas9 or similar technologies in mRNA format is preferred
- In-depth understanding of gene editing tools landscape (e.g., base editing) is preferred
- Familiarity with NGS assay development, primary cell culture, imaging/flow cytometry and RNA delivery methods (lipofection or LNP and nucleofection) is a plus
- Excellent communication, organization, and technical writing skills
- Solid problem-solving skills and the ability to work in a team-oriented setting
By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in
Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
In an effort to protect our coworkers and communities from COVID-19, where permitted by law Vor Biopharma Inc. requires all employees to be fully vaccinated against COVID-19 and up to date with their vaccination unless they receive an approved reasonable accommodation for medical or religious reasons.