Career | <?phpecho $jobTitle;?> | <?phpecho $companyName;?>

Umbra - Principal Scientist/Associate Director (Proteomics Chemical Biology)


Lexington, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Industry: Life Science
  • Post Date: 05/30/2023
  • Website:
  • Company Address: 200 Berkeley Street, 18th Floor, Boston, MA, 02116

About RAVen

RAVen (RA Ventures) is the venture-focused arm of RA Capital Management, LP, a Boston-based biotechnology and life sciences investment firm.

Job Description

Umbra Therapeutics is mapping the tyrosine and lysine proteome to develop impactful therapeutics against diverse target classes.  We are integrating advanced chemoproteomics technologies & bioinformatics with computational chemistry, structural biology and medicinal chemistry capabilities to develop novel, selective therapies in oncology.  Our capabilities enable targeting of non-cysteine amino acids to discover novel druggable protein sites and inform rational drug design. Our vision is to be the premier company building a pipeline of next-generation small molecule therapeutics for high-value protein targets.  

About the Role:

Umbra Therapeutics is searching for a creative, resourceful, and passionate (chemical) proteomics scientist to join our mission of developing small molecule oncology therapeutics. The role requires an individual with a proven track record of developing innovative proteomics solutions to drive drug discovery decisions. The candidate will have strong interdisciplinary skills, an aptitude for people management, and will be a key team player in the broader company objectives. The role will report to the Head of Chemical Biology & Proteomics.


  • Lead the design, execution, and communication of proteomics team deliverables that enable project decisions
  • Identify and leverage external partners with complementary knowledge and capabilities to achieve team goals
  • Provide timely and well-organized presentations at regular project meetings
  • Collaborate effectively with all Umbra team members

Required Qualifications:

  • Doctoral degree (PhD) or equivalent industry experience in proteomics, chemical biology, analytical chemistry or related discipline 
  • 3+ years of experience in the pharmaceutical/biotech industry with a strong track record of delivering innovative proteomics data to drive interdisciplinary projects
  • Extensive hands-on experience in discovery proteomics including sample preparation, analytical method development, instrument operation, and data analysis
  • Demonstrated technical proficiency, scientific creativity, independent thought, and ability to effectively collaborate and lead others
  • Experience managing or mentoring interns or other junior scientists
  • Thrives working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful, and efficient. Excellent problem-solving ability and attention to detail are critical. 
  • Demonstrated ability to communicate complex issues in a simple way and to orchestrate plans to resolve issues and mitigate risks
  • Must excel in a multidisciplinary environment as an integral team member across several project teams
  • Embrace the Umbra’s culture of patient first
  • Excitement about the vision and mission of Umbra Therapeutics. 
  • This role will require the ability and willingness to work in our Lexington, MA site with a flexible hybrid schedule

Preferred Qualifications:

  • Track record of determining compound mechanism of action or small molecule hit discovery using proteomics approaches
  • Experience with one or more of the following: targeted proteomics; intact mass or top-down proteomics; automated sample preparation; computational proteomics; and post-translational modification analysis