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Sr. Associate Scientist, Downstream Development for Protein Development & Manufacturing


San Carlos, CA, US
  • Job Type: Full-Time
  • Function: Manufacturing
  • Industry: Vaccine
  • Post Date: 05/23/2023
  • Website:
  • Company Address: 353 Hatch Drive, Foster City, CA, 94404

About Vaxcyte

High-fidelity vaccines against pneumococcal infection and other bacterial infections

Job Description

Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte’s pipeline also includes VAX-31, a 31-valent PCV candidate; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease; and VAX-GI, a vaccine program designed to prevent Shigella. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit
Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 180 employees and anticipates continued, significant growth. Following equity offerings in October 2022 and April 2023, which generated over $1.1 billion in net proceeds, the Company’s balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. These financings followed positive data readouts from Vaxcyte’s Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64 and Phase 2 study in adults 65 and older. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children. VAX-24 is being investigated for the prevention of IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte’s PCV franchise, consisting of VAX-24 and VAX-31, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease. We believe that our PCVs could receive regulatory approval based on successful completion of clinical studies utilizing well-defined surrogate immune endpoints, consistent with how other PCVs have obtained regulatory approval in the past, rather than requiring clinical field efficacy studies.
Vaxcyte is looking for an energetic and talented individual to join our protein process development and manufacturing group.  As a member of this group, you’ll have the opportunity to work with cutting edge technologies to design purification processes for life-saving vaccines.    The successful candidate will have the following skills and qualities:
·An exceptional team member that fosters a highly collaborative work environment.
·A confident individual who speaks up, is open to input, and remains focused on achieving the best results to achieve company goals.
·A diligent scientist/engineer who enjoys process execution and scale up.
·The ability to clearly present data, trend longitudinal data, draw conclusions, and communicate salient points concisely.
·A strong sense of ownership and accountability; commitment to Vaxcyte’s mission.

Essential Functions:

    • Execution of chromatography, tangential flow filtration, and normal flow filtration systems.
    • Create process records that clearly instruct and efficiently facilitate capture of data.
    • Execute protein purifications specifically AKTA chromatography systems and UNICORN software.
    • Conduct analytical methods a plus; such methods may include SDS-PAGE, Endosafe, UV spectroscopy, and HPLC.
    • Support scale up activities for processes as part of technology transfer to CMOs.
    • Contribute to process development for protein processes.
    • Run in-process tests and product quality assays to support pilot production.
    • Participate in technology transfer activities for the process developed at Vaxcyte to an external CMO for GMP production.
    • Plan and manage logistics of routine pilot production of proteins to support Vaxcyte’s pipeline.


    • BS in Chemical Engineering, Biochemistry, or a related discipline, with 5-8 +years of industry experience. Preferably in Process Development.
    • Strong protein purification knowledge and experience, including familiarity with AKTA   chromatography systems and UNICORN software.
    • Proficiency running analytical methods a plus; such methods may include SDS-PAGE, Endosafe, UV spectroscopy, and HPLC.
    • Experience operating tangential flow filtration systems; single-pass TFF is a plus.
    • Experience with Benchling ELN is a plus.
    • Strong interpersonal skills, with excellent written and verbal communication skills.
    • All Vaxcyte employees require vaccination against COVID-19.
Reports to: Associate Director, Downstream Development for Protein Development & Manufacturing
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $107,000 - $121,000