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Synolo - Associate Scientist/Scientist, Protein Science


Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Industry: Life Science
  • Post Date: 12/04/2023
  • Website:
  • Company Address: 200 Berkeley Street, 18th Floor, Boston, MA, 02116

About RAVen

RAVen (RA Ventures) is the venture-focused arm of RA Capital Management, LP, a Boston-based biotechnology and life sciences investment firm.

Job Description

Synolo Therapeutics, an early-stage biotechnology company launched by RA Capital, is pioneering the development of precision-targeted immunotherapies for cancer. Powered by computational protein design and proprietary technologies which yield biological data sets at unprecedented scale and resolution, we are building a pipeline of first-in-class multi-specific biologics with novel functionalities. Synolo was founded by pioneers in the field of protein design and engineering, synthetic biology, DNA sequencing, immunology, and biologics drug discovery and development. 

About RA Capital:

RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. TechAtlas' analyses are captured in a unique collection of competitive landscapes, or ‘maps’, that identify competitive therapeutics, diagnostics, research tools, and/or technological capabilities in a given area.

About the Role:

Synolo Therapeutics is seeking an innovative, self-motivated, and team-oriented Associate Scientist/ Scientist in Protein Science, with a passion for discovering and developing novel medicines and who thrives working in a fast-paced startup team. In this role, you will contribute to the expression, purification and characterization of antibody drug leads and protein reagents. In addition, you will support our cross-functional teams with your profound knowledge of Protein Science and be a key contributor to our drug discovery and development programs. As a member of a rapidly growing and very engaged team, you will help us in our mission to develop novel therapeutics to improve patients’ lives.

Key Responsibilities:

  • Key contributor to the maintenance and growth of in-house capabilities of protein expression in mammalian cells (eg. CHO) and of protein purification to support research activities, project goals and platform development.
  • Design and carry out experiments to express multi-specific biologics
  • Characterize the purified leads biochemically and biophysically
  • Study protein solubility and stability with various biophysical techniques
  • Analyze and communicate experimental results verbally and in writing

Qualifications & Skills:

  • BA/MA or PhD in Biochemistry, Molecular Biology, Biomedical Engineering or a related field. Level commensurate with experience.
  • Hands-on experience in mammalian cell culture and expression and purification of recombinant antibodies and/or other classes of proteins 
  • Hands-on experience in protein purification using FPLC systems and familiarity with several types of chromatography (Protein A/G affinity, IMAP, ion exchange,  SEC, HIC)
  • Hands-on experience with current molecular biology and cell biology techniques, including mammalian cell culture and transfection, Western blot, SDS-PAGE, ELISA etc
  • Hands-on experience with characterization of antibody on HPLC, such as reverse phase, SEC, AEX, and/or CEX)
  • Hands-on experience in determining binding kinetics and affinity between antigen and antibody (SPR, BLI, or monolith)
  • Hands-on experience in characterization of antibody, such as DSF, DLS, and/or sec-MALS 
  • Strong analytical skills, with attention to detail and ability to multi task, with good follow through on action items
  • Strong interpersonal skills, with the ability to build strong working relationships with cross-functional teams
  • Strong communication skills

Preferred Experience:

  • Hands-on experience with expressing, purifying and characterizing bi-specific or multi-specific biologics a strong plus
  • Hands-on experience in making expression constructs