About TRIANA Biomedicines: 

TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients. TRIANA is a private company with a top-tier investor syndicate. 

Role: 

The Biology and Translational Sciences group at TRIANA Biomedicines is seeking a passionate and independent Senior Scientist to help drive discovery and early translational biology activities for pre- portfolio and pipeline programs. The qualified candidate will join a growing team of dedicated researchers seeking to deliver on TRIANA’s target-first approach to molecular glue discovery. 

Responsibilities: 

• Use genetic tools to link target degradation to phenotypic response in disease-relevant models  
• Develop and carry out cell-based assays to monitor cellular target engagement, ubiquitination,
  target protein degradation, and downstream signaling events  
• Design and execute experiments to understand the mechanism of action of proprietary molecular glue degraders for high value oncology targets 
• Record, interpret, and communicate data promptly 
• Present data in team and company meetings.