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Associate Scientist II, Bioanalytical Chemistry

Vor Bio

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Oncology
  • Post Date: 10/29/2024
  • Website: www.vorbio.com
  • Company Address: 100 Cambridgepark Dr, Suite 101, Cambridge, MA, 02140

About Vor Bio

Vor Bio is a clinical-stage cell and genome engineering company that aims to change the standard of care for patients with blood cancers by engineering hematopoietic stem cells to enable targeted therapies post-transplant.

Job Description

We create shielded stem cell transplants that enable targeted therapies to attack only cancer cells

Every year, thousands of patients with Acute Myeloid Leukemia (AML) and other blood cancers relapse post-transplant with no safe and effective treatment options. Vor Bio’s approach provides the first opportunity to deliver potentially curative treatments post-transplant.

Our novel platform creates a shielded stem cell transplant that is designed to enable multiple modalities and therapies, including Antibody Drug Conjugates (ADCs) and Chimeric Antigen Receptor T (CAR-T) cells, which could potentially be effective against the tumor, but are toxic to normal cells. Vor’s genetically engineered transplant provides a protective shield to the healthy cells and thereby allows the cancer cells to be specifically targeted for destruction.

By shielding healthy cells, Vor Bio is aiming to potentially cure Acute Myeloid Leukemia (AML) and other blood cancers. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines

Fellowship: Fostering genuine bonds of collaboration and mentorship

Humility: Acting selflessly by putting the collective mission first

Who we are looking for

Vor Bio is seeking an Associate Scientist II, to join our Bioanalytical Chemistry team. The successful candidate will be integral in developing and executing robust analytical assays for critical starting materials used in our novel therapies. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients. This position will be reporting to the Bioanalytical Chemistry Group in the Process and Analytical Development team at Vor Bio. This group is responsible for developing, optimizing, executing, evaluating, validating, transferring bioanalytical assays primarily HPLC/UPLC/LCMS-based analytical methods and using these methods to characterize the critical starting materials used in developing our therapies.

Key areas of responsibility

  • Execute HPLC-based or other bioanalytical assays independently following established protocols - involving data acquisition, mobile phase/buffer preparation, instrument maintenance, troubleshooting, data analysis and report generation
  • Methodically test various conditions for new assay development and optimization
  • Maintain a detailed and updated ELN record of experiments conducted
  • Analyze and visualize experiment data
  • Collaborate with other groups/teams to perform in-process testing of materials and complete reporting workflows for those data in a timely manner
  • Write SOPs and update SOPs of existing assays in established non-GXP or GXP workflows as needed
  • Work cross-functionally to learn new platforms/assays that can be used to characterize raw materials
  • Perform literature searches to inform experiment design
  • Present study designs and results to internal and external stakeholders communicating in an effective manner to drive decision-making among stakeholders
  • Support and maintain critical starting material inventory, distributing critical starting materials as needed for studies and maintaining updated records of material distribution

Qualifications

  • BS Coursework in Biochemistry or Biotechnology
  • 2+ years of analytical chemistry/biochemistry lab-based experience
  • Ability to work collaboratively in a team environment
  • Ability to consistently deliver exceptional results with impeccable attention to detail
  • Self-driven and motivated to excel
  • Ability to pivot in a fast-paced industry
  • Excellent problem-solving and communication skills
  • Creative, analytical and action-oriented mindset
  • Training in basic lab safety/chemical safety and various sample prep techniques
  • Track record of intellectually challenging oneself to enhance scientific capabilities

Preferred Qualifications

  • MS Coursework and/or co-op/internship experience in Analytical Biochemistry is preferred
  • 1+ years of experience with HPLC/ Chromatography methods development/optimization is preferred
  • 1+ years of experience designing and set-up of complex study designs; eg. Stability study

By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.